Boronic acid, B-(1,2-dihydro-5-acenaphthylenyl)-
ACENAPHTHENE-5-BORONIC ACID
CAS: 183158-33-0
Molecular Formula: C12H11BO2
Boronic acid, B-(1,2-dihydro-5-acenaphthylenyl)- - Names and Identifiers
Boronic acid, B-(1,2-dihydro-5-acenaphthylenyl)- - Physico-chemical Properties
| Molecular Formula | C12H11BO2 |
| Molar Mass | 198.03 |
| Density | 1.28±0.1 g/cm3(Predicted) |
| Melting Point | 270°C(lit.) |
| Boling Point | 429.9±53.0 °C(Predicted) |
| pKa | 9.11±0.20(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Boronic acid, B-(1,2-dihydro-5-acenaphthylenyl)- - Risk and Safety
| WGK Germany | 3 |
Boronic acid, B-(1,2-dihydro-5-acenaphthylenyl)- - Reference Information
| application | naphtholamine-5-boronic acid can be used as an intermediate in pharmaceutical synthesis, and can be used in laboratory organic synthesis process and chemical pharmaceutical synthesis process. |
| preparation | naphthylpentane -5-boric acid preparation is as follows: 11.7g of commercial 5-bromoacenaphthene is dissolved in 50ml of anhydrous toluene and 50ml of anhydrous ether mixed solvent, and the obtained solution is cooled to -40°C under argon atmosphere. A hexane solution of 35ml of 1.6M n-butyl lithium was added dropwise to the resulting solution, and the temperature was subsequently raised to -10°C. After 2 hours, the resulting solution was cooled to -70°C, and then another solution prepared by dissolving 35ml of triisopropoxyborane in 50ml of ether was added dropwise to the solution. The resulting solution was stirred for 3 hours at -70°C and then left to stand overnight. After one night, the solution obtained was acidified with 10% weight of dilute hydrochloric acid and the organic layer was extracted with toluene. The organic layer is washed with dilute hydrochloric acid and saturated sodium chloride solution, dried by anhydrous sodium sulfate, and the organic solvent is distilled with an evaporator. The residue was crystallized using toluene/hexane to obtain 4.5g (yield 45%) naphthol-pentane-5-boronic acid. |
Last Update：2024-04-09 21:11:58
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